Pineapple fruit extract (Ananas comosus L. Merr) as an antioxidant and anti-acne agent made with the nano-emulsion gel delivery system

Chabib, Lutfi and Suryani, Arman and Dewi, Loly Sintia and Noviani, Herdwi and Maharani, Widya Husna Puspa and Indraswari, Aina Anasta (2023) Pineapple fruit extract (Ananas comosus L. Merr) as an antioxidant and anti-acne agent made with the nano-emulsion gel delivery system. Pharmacy Education, 23 (2). 126 – 132. ISSN 15602214

[thumbnail of Arman Suryani_FA.pdf] Text
Arman Suryani_FA.pdf - Published Version
Restricted to Registered users only

Download (432kB) | Request a copy

Abstract

Background: Pineapple (Ananas comosus L. Merr) contains a lot of fibre, minerals, and vitamins. Consequently, it has anti-inflammatory, antibacterial, antioxidant, and antidiabetic benefits. Objective: The purpose of this research was to produce pineapple extracts in the form of nano-emulsion gel for more effective use as an antioxidant and anti-acne. Method: The extraction was done by maceration. The resulting extracts were formulated with tween 20 and propylene glycol, while kollisolv PYR served as the oil phase. A nano-emulsion was then formed and formulated into a gel. Result: In this study, the nano-emulsion gel produced was transparent yellowish-white, slightly viscous, with a characteristic odour, a particle size of 10.8 nm ± 0.5, a polydispersity index of 0.239 Ð ± 0.1 and a zeta potential of -33.6 mV ± 1.3. The ability of this nano-emulsion gel to spread was good, 10.28 cm - 14.48 cm, with 1.31 seconds of adhesion and the result of the viscosity test of 3667.4 ± 106.03 cP. In the antioxidant test, the RSA was produced in the range of 17.70 - 70.32 and the IC50 value was 0.1 μg/mL so it was included in the category of very strong antioxidant. While the anti-acne test has an average bacterial inhibition zone of 10.5 mm ± 0.1 which is in the category of strong anti-acne. Conclusion: It was concluded that pineapple fruit extract with a nano-emulsion gel base can produce good nanoparticle preparations, which have very strong antioxidant and anti-acne activities. © 2023 FIP.

Item Type: Article
Additional Information: Cited by: 1; All Open Access, Gold Open Access
Uncontrolled Keywords: anti acne agent; antioxidant; gel; nanoparticle; plant extract; polysorbate 20; adhesion; antioxidant activity; Article; controlled study; dispersity; drug delivery system; drug isolation; IC50; nanoemulsion; nonhuman; odor; particle size; pineapple; viscosity; zeta potential; zone of inhibition
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy
Depositing User: Sri JUNANDI
Date Deposited: 30 Oct 2024 20:22
Last Modified: 30 Oct 2024 20:22
URI: https://ir.lib.ugm.ac.id/id/eprint/6043

Actions (login required)

View Item
View Item