Optimization, Characterization and Ex-vivo permeation of Nanoemulsion containing Diclofenac sodium as the development of Novel Nano-drug Delivery System

Muhtadi, Wildan Khairi and Nugroho, Bambang Hernawan and Indrati, Oktavia and Martien, Ronny and Nofriyanti, Nofriyanti (2023) Optimization, Characterization and Ex-vivo permeation of Nanoemulsion containing Diclofenac sodium as the development of Novel Nano-drug Delivery System. Research Journal of Pharmacy and Technology, 16 (5). 2257 – 2264. ISSN 09743618

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Abstract

This study aimed to optimize the diclofenac sodium (DS)-loaded nanoemulsion (DSNE)s components, to characterize the optimum formula of DSNEs, including determining its skin penetration ability. DSNEs were optimized by the aqueous titration method to decide the optimum ratio of each component. The yielded diagram of pseudo-ternary phase was used on the considerationof the optimum formulas. The characterization of three optimum DSNEs was done by measuring the globule size, polydispersity index, zeta potential, pH, viscosity, kinetic stability, and ex-vivo permeation. One Way ANOVA (95 confidence interval) was used to analyze the cumulative DS penetrated. The optimum formulations were found with the oil:smix (surfactant:cosurfactant) ratio of 1:7(1:1), 1:7(2:1), and 1:7(3:1), which coded as DSNE1, DSNE2, and DSNE3, respectively. The three optimum formulations possessed the average droplet size of below 200nm, polydispersity index of lower than 0.7, and zeta potential of above -30 mV, respectively. There were no phase separations in the centrifugation test. DSNE3 possessed the highest DS penetrated and flux compared to other formulations. The optimization of DSNEs yielded three optimum formulations with good characteristics in accordance with the acceptance criteria of nanoemulsions. Furthermore, the smaller particle size and higher concentration of T80 enhanced the ability of DS penetration. © 2023, Research Journal of Pharmacy and Technology. All rights reserved.

Item Type: Article
Additional Information: Cited by: 0
Uncontrolled Keywords: diclofenac; animal tissue; Article; dispersity; drug delivery system; drug formulation; drug stability; male; membrane transport; mouse; nano drug delivery system; nanoemulsion; nonhuman; particle size; permeability; pH; phase separation; rat; skin penetration; ultraviolet spectrophotometry; viscosity; zeta potential
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy
Depositing User: Sri JUNANDI
Date Deposited: 01 Nov 2024 01:31
Last Modified: 01 Nov 2024 01:31
URI: https://ir.lib.ugm.ac.id/id/eprint/6057

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