The Effect of Extraction Method of Vernonia Amygdalina Delile. Leaves on Cardiotonic Effect

Satria, Denny and Harahap, Urip and Dalimunthe, Aminah and Hertiani, Triana and Syahputra, Rony Abdi and Muhammad, Mahatir and Nasri, Nasri (2023) The Effect of Extraction Method of Vernonia Amygdalina Delile. Leaves on Cardiotonic Effect. Farmacia, 71 (2). 392 – 396. ISSN 00148237

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Abstract

Vernonia amygdalina Delile leaves contain secondary metabolites that prevent heart disease. This study aims at demonstrating the cardiotonic effect of various ethanolic extracts obtained with simplicia powder of African leaf. In this direction, we tested the effect of African leaf ethanolic extract on normal rat heart isolates and determined its effect on heart contractility and heart rate. The results showed that the highest cardiac glycoside content in the ethanolic extract obtained by reflux extraction was 30.05 ± 0.13 mg/g. In an inotropic test, the same extract with a concentration of 1 mg/mL increased contractility by 74.02, and regarding the chronotropic test, an 22.68 increase was observed. African leaf ethanolic extract (from Vernonia amygdalina Delile), obtained using reflux method, with a 1 mg/mL concentration, exhibited positive inotropic and chronotropic activity.

Item Type: Article
Additional Information: Library Dosen
Uncontrolled Keywords: Vernonia amygdalina Delile, cardiotonic, inotropic, chronotropic
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy
Depositing User: Sri JUNANDI
Date Deposited: 31 Oct 2024 04:21
Last Modified: 31 Oct 2024 04:21
URI: https://ir.lib.ugm.ac.id/id/eprint/6093

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