The role of plasma angiotensin-converting enzyme and interleukin-6 levels on the prognosis of non-dialysis chronic kidney disease patients; Papel de los niveles plasmáticos de la enzima convertidora de angiotensina e interleucina-6 en el pronóstico de los pacientes con enfermedad renal crónica no sometidos a diálisis

Susilo, Hendri and Thaha, Mochammad and Pikir, Budi Susetyo and Alsagaff, Mochamad Yusuf and Suryantoro, Satriyo Dwi and Wafa, Ifan Ali and Pratama, Nando Reza and Budi, David Setyo and Wiratama, Bayu Satria and Wungu, Citrawati Dyah Kencono (2023) The role of plasma angiotensin-converting enzyme and interleukin-6 levels on the prognosis of non-dialysis chronic kidney disease patients; Papel de los niveles plasmáticos de la enzima convertidora de angiotensina e interleucina-6 en el pronóstico de los pacientes con enfermedad renal crónica no sometidos a diálisis. Journal of Pharmacy and Pharmacognosy Research, 11 (1). 55 – 62. ISSN 07194250

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Abstract

Context: Inflammatory factors and oxidative stress were discovered to play significant roles in the progression of chronic kidney disease (CKD). There is, however, no research on the direct impact of high plasma angiotensin converting enzyme (ACE) and interleukin (IL)-6 levels on CKD prognosis, particularly in non-hemodialysis patients. Aims: To investigate the potential role of plasma ACE and IL-6 levels in CKD prognosis. Methods: A total of 75 non-dialysis CKD patients participated in this cross-sectional study. The estimated glomerular filtration rate (e-GFR) and albuminuria were used to determine the prognosis of CKD. The plasma ACE and IL-6 levels were measured using an enzyme-linked immunoassay (ELISA). Spearman's rank correlational analysis was used to examine the relationship between ACE and IL-6 plasma levels with the prognosis of CKD. Results: The result showed a statistically significant correlation between age and plasma ACE (p = 0.038, r = 0.241), serum creatinine, and urine albumin-creatinine ratio with CKD prognosis (p<0.0001). A negative significant correlation was found between the e-GFR and CKD prognosis (p<0.0001). Additionally, there were also significant correlations between plasma ACE and IL-6 with CKD prognosis (p = 0.021, r = 0.266 and p = 0.04, r = 0.238, respectively). A significant positive correlation was also found between plasma ACE and IL-6 (p = 0.024, r = 0.260). Conclusions: There was a significant correlation between plasma ACE and IL-6 levels with CKD prognosis. Further investigation revealed a statistically significant positive relationship between plasma ACE and IL-6 levels. © 2023 Journal of Pharmacy & Pharmacognosy Research.

Item Type: Article
Additional Information: Cited by: 0; All Open Access, Gold Open Access
Uncontrolled Keywords: dipeptidyl carboxypeptidase; interleukin 6; adult; age; albumin to creatinine ratio; albuminuria; angiotensin blood level; Article; chronic kidney failure; controlled study; creatinine blood level; cross-sectional study; enzyme linked immunosorbent assay; estimated glomerular filtration rate; female; gene expression; hemodialysis; human; human tissue; major clinical study; male; prognosis; protein blood level; protein function
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Sri JUNANDI
Date Deposited: 07 Oct 2024 01:09
Last Modified: 07 Oct 2024 01:09
URI: https://ir.lib.ugm.ac.id/id/eprint/6111

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