Li, Shunyi and Yakabe, Kyosuke and Zai, Khadijah and Liu, Yiwei and Kishimura, Akihiro and Hase, Koji and Kim, Yun-Gi and Mori, Takeshi and Katayama, Yoshiki (2021) Specific adsorption of a β-lactam antibiotic: In vivo by an anion-exchange resin for protection of the intestinal microbiota. Biomaterials Science, 9 (21). 7219 – 7227. ISSN 20474830
Full text not available from this repository. (Request a copy)Abstract
The fraction of antibiotics that are excreted from the intestine during administration leads to disruption of commensal bacteria as well as resulting in dysbiosis and various diseases. To protect the gut microbiota during treatment with antibiotics, use of activated carbon (AC) has recently been reported as a method to adsorb antibiotics. However, the antibiotic adsorption by AC is nonspecific and may also result in the adsorption of essential biological molecules. In this work, we reported that an anion exchange resin (AER) has better specificity than AC for adsorbing the β-lactam antibiotic cefoperazone (CEF). Because CEF has a negatively charged carboxylate group and a conjugated system, the AER was used to adsorb CEF through electrostatic and π-π interactions. The AER was specific for CEF over biological molecules such as bile acids and vitamins in the intestine. The AER protected Escherichia coli from CEF in vitro. Furthermore, oral administration of the AER reduced the fecal free CEF concentration, and protected the gut microbiota from CEF-induced dysbiosis. This journal is © The Royal Society of Chemistry.
Item Type: | Article |
---|---|
Additional Information: | Cited by: 4 |
Uncontrolled Keywords: | Adsorption; Anion Exchange Resins; Anions; Anti-Bacterial Agents; beta-Lactams; Gastrointestinal Microbiome; Activated carbon; Adsorption; Antibiotics; Carboxylation; Escherichia coli; Molecules; anion exchange resin; bile acid; carboxylic acid; cefixime; cefoperazone; cefotaxime; DNA 16S; vitamin; anion; anion exchange resin; antiinfective agent; beta lactam; Adsorption by activated carbon; Anion exchange resins; Biological molecule; Cefoperazone; Gut microbiota; In-vivo; Microbiotas; Negatively charged; Specific adsorption; β-lactam antibiotics; animal cell; animal tissue; Article; controlled study; drug adsorption; Escherichia coli; in vitro study; in vivo study; intestine flora; isotherm; male; mouse; nonhuman; adsorption; Ion exchange resins |
Subjects: | R Medicine > RS Pharmacy and materia medica |
Divisions: | Faculty of Pharmacy |
Depositing User: | Sri JUNANDI |
Date Deposited: | 30 Oct 2024 02:12 |
Last Modified: | 30 Oct 2024 02:12 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/8426 |