The therapeutic outcomes and adverse drug reactions study of Clozapine on Schizophrenia inpatients in the Grhasia psychiatric hospital Yogyakarta, Indonesia

Harjaningsih, Woro and Ayunirrahmah, Laila and Putri, Nur Jannah Virsya (2021) The therapeutic outcomes and adverse drug reactions study of Clozapine on Schizophrenia inpatients in the Grhasia psychiatric hospital Yogyakarta, Indonesia. PHARMACY EDUCATION, 21 (2). pp. 287-295. ISSN 1560-2214

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Abstract

Introduction: Clozapine is an antipsychotic agent used in schizophrenia recurrence or when other antipsychotics are not effective. Aims: This study aims to determine the therapeutic outcome and adverse drug reactions of clozapine in schizophrenia disorder among hospitalised patients. Methods: A retrospective cross-sectional study was conducted between January 2018 and December 2019 using inpatients' medical records from the Grhasia Psychiatric Hospital, Yogyakarta. The therapeutic outcome was measured with the PANSS-EC scale, while adverse drug reactions of clozapine were analysed theoretically as per the literature. Results: The average decrease in the PANSS-EC score was 8.27, and the average duration to achieve this decrease was 2.5 days. The combination of typical-atypical antipsychotics could reduce the highest PANSS-EC score of 11-15 (41%). The adverse drug reactions of clozapine were tremor, weight gain, obesity, leucopenia, hyperglycemia, and hypercholesterolemia, among other effects. Conclusion: Clozapine is effective in improving positive and negative symptoms, but its use needs close monitoring.

Item Type: Article
Additional Information: 105th Educational Conference of the International-Association-for-Identification (IAI), Nashville, TN, AUG 01-07, 2021
Uncontrolled Keywords: Adverse drug reaction; Clozapine; Schizophrenia; Therapeutic outcome
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy
Depositing User: Sri JUNANDI
Date Deposited: 23 Oct 2024 00:52
Last Modified: 23 Oct 2024 00:52
URI: https://ir.lib.ugm.ac.id/id/eprint/8957

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