The combination of simplex lattice design and chemometrics in the formulation of green tea leaves as transdermal matrix patch

Setyawan, Eka Indra and Rohman, Abdul and Setyowati, Erna Prawita and Nugroho, Akhmad Kharis (2021) The combination of simplex lattice design and chemometrics in the formulation of green tea leaves as transdermal matrix patch. PHARMACIA, 68 (1). pp. 275-282. ISSN 0428-0296

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Abstract

Aim: This study was aimed to formulate a transdermal matrix patch using green tea leaf extract. Materials and methods: The transdermal matrix patch formulation was optimized by the simplex lattice design method. The correlation between responses was analyzed using chemometrics. The observed responses were: 1. the physical properties of the matrix patch, and 2. the percentage of dissolution efficiency of catechins, caffeine, and epigallocatechin gallate released from the patch. The determination of drug release kinetics was based on the curve-fitting analysis using zero-order, first-order, Higuchi, and Korsmeyer-Peppas models. Results: The results showed that the optimal formula was obtained using the mixture of HPMC K100, HPMC K4M, and PEG 400 at a ratio of 4.0: 4.5: 0.5. The principal component analysis (PCA) showed that %DE300 values of catechin caffeine and epigallocatechin gallate positively correlate. A similar condition was observed between the weight and thickness of the matrix. Drug release kinetics follows the Korsmeyer-Peppas model.

Item Type: Article
Uncontrolled Keywords: green tea; patch; transdermal; simplex lattice design; chemometrics
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy
Depositing User: Sri JUNANDI
Date Deposited: 19 Oct 2024 08:01
Last Modified: 19 Oct 2024 08:01
URI: https://ir.lib.ugm.ac.id/id/eprint/9197

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