Wahdaningsih, Sri and Wahyuono, Subagus and Riyanto, Sugeng and Murwanti, Retno (2021) Y B-Sitosterol of Red Dragon Fruit (<i>Hylocereus Polyrhizus</i>) And Its Response to Macrophage And Nitric OxideY. INDONESIAN JOURNAL OF PHARMACY, 32 (3). pp. 399-407. ISSN 2338-9486
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Y Hylocerius polyrhizus has relatively big potency as natural antioxidant. The compound considered as antioxidant also has immunomodulatory activity. This study showed isolation to identifying Hylocereus polyrhizus peels active compounds to increase immune system of human body. The methanol extracts were partitioned and fractionated. Petroleum ether fraction active compounds were partitioned and purified using Preparative Thin Layer Chromatography (PTLC). Active compound structures was identificated with spectroscopy: UV, FT-IR, (CNMR)-C-13, (HNMR)-H-1, DEPT and HSQC. The immunomodulatory activity was also tested. Based on the spectroscopic data, the identified isolate was beta-sitosterol. Macrophage cell activity and nitric oxide showed that isolates at the highest concentrations of 100 mu g/mL were able to activate macrophage cells and enhance the production of nitric oxide.
Item Type: | Article |
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Uncontrolled Keywords: | H. polyrhizus; beta-sitosterol; macrophage; nitrit oxide |
Subjects: | R Medicine > RS Pharmacy and materia medica |
Divisions: | Faculty of Pharmacy |
Depositing User: | Sri JUNANDI |
Date Deposited: | 19 Oct 2024 06:34 |
Last Modified: | 19 Oct 2024 06:34 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/9199 |