Taroeno-Hariadi, Kartika Widayati and Putra, Yasjudan Rastrama and Choridah, Lina and Widodo, Irianiwati and Hardianti, Mardiah Suci and Aryandono, Teguh (2021) Fatty Liver in Hormone Receptor-Positive Breast Cancer and Its Impact on Patient's Survival. JOURNAL OF BREAST CANCER, 24 (5). pp. 417-427. ISSN 1738-6756
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Purpose: Long-term estrogen inhibition may cause fatty liver disease (non-alcoholic fatty liver disease; NAFLD) among other adverse conditions such as osteoporosis, climacteric symptoms, thromboembolism, dyslipidemia, and metabolic syndrome. The prevalence of NAFLD among breast cancer patients ranges from 2.3%-45.2%. This study aimed to determine the risk factors for newly developed NAFLD among breast cancer patients after hormonal treatment and whether it influences survival outcomes. Methods: This retrospective study investigated hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative (HR+/HER2-), nonmetastatic breast cancer patients diagnosed between January 2010 and December 2018. All patients received adjuvant hormonal treatment for at least 6 months. Clinical data on metabolic profile indicators such as body mass index (BMI), waist circumference, serum cholesterol, triglycerides, low-density lipoprotein-cholesterol (LDL-C), high-density lipoproteincholesterol (HDL-C), diabetes, and presence of metabolic syndrome (MetS) were collected. In total, 160 eligible patients with complete covariate data and survival follow-tip were included. Results: NAFLD was diagnosed in 35% of patients. There were significant associations of being overweight (BMI >= 25 kg/m(2)), waist circumference > 80 cm, triglycerides 150 mg/dL, HDL-C <= 50 mg/dL, LDL-C < 150 mg/dL, and presence of MetS with the development of NAFLD. However, unlike other factors, MetS and HDL-C were not independently associated with NAFLD. Patients with breast cancer who developed NAFLD had longer disease-free survival (DFS). The median DFS was not reached in the NAFLD group, whereas it was 59.3 (45.6-73.0) months in the non-NAFLD group. No worsening of overall survival was observed in patients with breast cancer and NAFLD. Conclusion: The development of NAFLD during treatment in patients with HR+/HER2-breast cancer was associated with several independent risk factors: being overweight, waist circumference, triglycerides, and LDL-C. Interestingly, breast cancer patients with NAFLD during treatment had longer DFS than those without NAFLD.
Item Type: | Article |
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Uncontrolled Keywords: | Aromatase inhibitors; Breast neoplasms; Fatty liver; Non-alcoholic fatty liver disease; Tamoxifen |
Subjects: | R Medicine > RB Biomedical Sciences |
Divisions: | Faculty of Medicine, Public Health and Nursing > Biomedical Sciences |
Depositing User: | Sri JUNANDI |
Date Deposited: | 18 Oct 2024 02:03 |
Last Modified: | 18 Oct 2024 02:03 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/9263 |