Satria, Denny and Harahap, Urip and Dalimunthe, Aminah and Hertiani, Triana and Syahputra, Rony Abdi and Muhammad, Mahatir and Nasri, Nasri (2023) THE EFFECT OF EXTRACTION METHOD OF VERNONIA AMYGDALINA DELILE. LEAVES ON CARDIOTONIC EFFECT. Farmacia, 71 (2). 392 – 396. ISSN 00148237
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Vernonia amygdalina Delile leaves contain secondary metabolites that prevent heart disease. This study aims at demonstrating the cardiotonic effect of various ethanolic extracts obtained with simplicia powder of African leaf. In this direction, we tested the effect of African leaf ethanolic extract on normal rat heart isolates and determined its effect on heart contractility and heart rate. The results showed that the highest cardiac glycoside content in the ethanolic extract obtained by reflux extraction was 30.05 ± 0.13 mg/g. In an inotropic test, the same extract with a concentration of 1 mg/mL increased contractility by 74.02, and regarding the chronotropic test, an 22.68 increase was observed. African leaf ethanolic extract (from Vernonia amygdalina Delile), obtained using reflux method, with a 1 mg/mL concentration, exhibited positive inotropic and chronotropic activity. © 2023, Romanian Society for Pharmaceutical Sciences. All rights reserved.
| Item Type: | Article |
|---|---|
| Additional Information: | Cited by: 3; All Open Access, Gold Open Access |
| Uncontrolled Keywords: | 3,5 Dinitrobenzoic acid; alcohol; bicarbonate; calcium chloride; carbogen; cardiac glycoside; digoxin; distilled water; Dragendorrf; ferric chloride; flavonoid; glucose; glycoside; heparin; ketamine; lactone; magnesium sulfate; Mayer; plant extract; potassium chloride; potassium hydrogen sulphate; saponin; sodium chloride; sodium hydroxide; steroid; tannin; terpene; unclassified drug; animal experiment; Article; cardiac muscle cell; Cardiotonic effect; colorimetry; dry powder; Gymnanthemum amygdalinum; heart contraction; heart disease; heart rate; Kedde reaction; medicinal plant; nonhuman; rat; Vernonia amygdalina Delile |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy |
| Depositing User: | Muh Aly Mubarok |
| Date Deposited: | 20 Jun 2025 08:35 |
| Last Modified: | 20 Jun 2025 08:35 |
| URI: | https://ir.lib.ugm.ac.id/id/eprint/9980 |
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